巨人的工具——超级女博士RhondaPerciavallePatrick

作者:jcmp      发布时间:2021-04-22      浏览量:0
原文:一、朗达·佩尔恰瓦莱·帕特里克朗达

原文:

一、朗达·佩尔恰瓦莱·帕特里克

朗达·佩尔恰瓦莱·帕特里克博士(TW/FB/IG:@FOUNDMYFITNESS,FOUNDMYFITNESS.COM)与很多名人共过事,其中包括布鲁斯·艾姆斯博士,他是艾姆斯试验(快速初筛化学致癌物的试验方法)的开创者,而且在1973—1984年里,他是第23位被各个领域引用最多的科学家。帕特里克博士也在索尔克生物研究所(位于美国加利福尼亚)进行一些临床试验和从事人类衰老的研究,并且还在圣犹大儿童医院做过关于癌症,线粒体新陈代谢和细胞死亡的毕业研究。最近,帕特里克博士发表了一篇关于维他命 D 是怎么样调节大脑血清素的产生和对生命早期缺陷与有关神经紊乱方面会产生众多影响的学术论文。

牙仙子可能会救你的命或者你孩子的命

帕特里克博士向我介绍了一种利用牙齿来建立干细胞储存的方法。如果你正在将你的智齿拔掉,又或者你的孩子正在换牙(你拔掉的智齿和孩子换下来的乳牙里面含有高浓度的牙髓干细胞),那么你可以考虑将牙齿交给像 StemSave 或者 National Dental Pulp Laboratory 这样的公司和专业机构进行托管,以便以后使用。这些公司和机构会送一个工具箱给你的口腔外科医生,将你的牙齿保存起来,然后利用液态氮进行冷冻储藏。虽然像类似的托管服务,各个公司费用会有所差异,但开户费用大概为625美元,再加上每年的保养费用125美元,费用基本也就这么多。

MSC( Mesenchymal stem cells)间充质干细胞可以从牙髓中产生,在特定的条件下,它可以分化为:骨,软骨,肌肉,血管等多种组织细胞。甚至还有可能救你的命,例如:利用你自己的牙髓干细胞作为原材料来治疗外伤性脑损伤。

高温(这里指桑拿)是一种新时尚

“高温调节”(适当的热辐射)可以帮助你提高生长激素水平和大幅度地提高耐久力。我现在每周至少4次在锻炼或者伸展运动后进行桑拿,一般温度大约调节在160-170℉(71-76℃)之间。如果没有其他异常,DOMS(延迟性肌肉酸痛)看起来会明显地减缓。

帕特里克博士着重在高温对于耐久力和生长激素的影响上做了观察和记录:

■ “一项研究表明:一周两次,每次30分钟的桑拿,持续三周,对于那些参与被研究的人而言,他们在锻炼后的持续时间增加了32%,也就是说耐久力增加了32%。在这项特殊研究中发现耐久力增加的这32%同时也增加了7.1%的血浆容量和3.5%的红血细胞数。”

■ “如果在176℉(80℃)条件下,进行两次时长都为20分钟的桑拿且中间隔时长为30分钟的冷却,那么这样就可以将生长激素水平提高到原来的两倍。而如果在212℉(100℃)的条件下,进行两次时长为15分钟的干蒸且中间间隔时长为30分钟的冷却,那么这样就可以将生长激素提高到原来的5倍…在进行桑拿以后, 生长激素通常会在体内维持两三个小时。”

TF: 泡热水澡也能显著地提高生长激素,而且泡热水澡和桑拿被证明可以大量地释放泌乳素(对女性孕育会有直接的影响),以及对伤口的修复也有一定的作用。我经常在浴室或者桑拿间里大约会呆上个20分钟,这样会显著地提高我的心率(适当地提高心率会有助于提高心脏的供氧能力)。我通常会推迟dynorphin 啡肽(是一种内成性的类吗啡生物化学合成物激素,由脑下垂体分泌,它能与吗啡受体结合,产生跟吗啡、鸦片剂一样有止痛和快感)的释放时间,这样做通常会使人感到焦虑不安和产生要出去透透气的想法(但这样做不会使人头晕)。通常,我会在蒸桑拿时听尼尔·盖曼的The Graveyard Book 《坟场之书》(一部非常著名的长篇科幻小说),然后再出去5-10分钟洗个冰浴(我通常会将40磅的冰放入浴缸里让温度大约保持在45℉(7℃);详细细节请见书本的43页)或者去喝冰水。以上的步骤我会反复做2-4次。

在去年(2015年)帕特里克博士学习和跟随的三个重要人物:布鲁斯·艾姆斯博士 Bruce Ames(之前提到的),Satchin Panda 博士 (加州圣地亚哥索尔克研究所的生物研究教授),Jennifer Doudna 詹妮弗·杜纳德 博士(加州大学伯克利分校的生物化学和分子生物学教授)。

译者笔记:

牙齿储存干细胞由于要在专业机构进行托管,所以有条件地可以尝试(但不管怎么说最起码我们知道了一种储存干细胞的方式,可以向亲戚朋友介绍,或许他们有这个需求)。桑拿,泡热水澡,冰浴(如果不敢尝试,可以喝冰水)这些我们都可以在特定的场所或者家里自己进行。

赶快试试吧!

原文:

二、RONDA PERCIAVALLE PATRICK

Rhonda Perciavalle Patrick , Phd (TW/FB/IG:@FOUNDMYFITNESS,FOUNDMYFITNESS.COM) has worked alongside notables including Dr.Bruce Ames, the inventor of the Ames mutagenicity test and the 23rd most-cited scientist across *all* fields between 1973 and 1984. Dr.Patrick also conducts clinical trials, performed aging research at the Salk Institute for Biological Studies , and did graduate research at St. Jude Children's Research Hospital, where she focused on cancer, mitochondrial metabolism, and apoptosis. More recently , Dr.Patrick has published papers on mechanism by which vitamin D is able to regulate the production of serotonin in the brain and the various implications this may have for early-life deficiency and relevance for neuropsychiatric disorders.

Spirit animal: Coywolf

THE TOOTH FAIRY MIGHT SAVE YOUR LIFE (OR YOUR KIDS’LIVES)。

Dr. Patrick introduced me to using teeth for stem-cell banking .If you are having your wisdom teeth removed , or if your kids are losing their baby teeth (which have a particularly high concentration of dental pulp stem cells), consider using a company like StemSave or National Dental Pulp Laboratory to preserve them for later use .These companies will send your oral surgeon a kit, and then freeze the biological matter using liquid nitrogen . Costs vary , but are roughly $625 for setup and then $125 per year for storage and maintenance.

Mesenchymal stem cells can later be harvested from the dental pulp of teeth for useful (e.g., bone ,cartilage muscle , blood vessels, etc. ), potentially life-saving (e.g., traumatic brain injury) treatments using your own biological raw materials.

三、HEAT IS THE NEW BLACK

“Hyperthermic conditioning” (calculated heat exposure) can help you to increase growth hormone (GH) levels and substantially improve endurance. I now take ~20-minute sauna sessions post-workout or post-stretching at least four times per week, typically at roughly 160 to 170℉

(71-76℃). If nothing else, it seems to dramatically decrease DOMS(delayed-onset muscle soreness).

Focusing on endurance and growth hormone, here are some observations from Dr. Patrick:

“One study has demonstrated that a 30-minute sauna session twice a week for 3 weeks post-workout increased the time it took for study participants to run until exhaustion by 32% compared to baseline. The 32% increase in running endurance found in this particular study was accompanied by a 7.1% increase in plasma volume and 3.5% increase in red blood cell count.”

“Two 20-minute sauna sessions at 176℉(80℃) separated by a 30-minute cooling period elevated growth hormone levels twofold over baseline. Whereas , two 15-minute dry-heat sessions at 212℉(100℃) separated by a 30-minute cooling period resulted in a five-fold increase in growth hormone … The growth hormone effects generally persist for a couple of hours post-sauna.”

TF: Hot baths can also significantly increase GH over baseline , and both sauna and hot baths have been shown to cause a massive release in prolactin , which plays a role in wound healing . I usually stay in a hot bath or sauna for about 20 minutes , which is long enough to significantly elevate my heart rate. I push a few minutes past dynorphin release , which usually makes one feel dysphoric and want to get out (but *not* to dizziness or lightheadedness ). Generally ,I’ll listen to an audiobook like The Graveyard Book by Neil Gaiman during the heat , then cool off for 5 to 10 minutes using an ice bath (I put 40 pounds of ice in a large bath to get it to roughly 45℉(7℃) ; more details on page 43) and/or by drinking ice water.I’ll repeat this cycle 2 to 4 times.

Three people Dr. Patrick has learned from or follows closely in the last year Dr. Bruce Ames , Dr. Satchin Panda (professor at the Salk Institute in San Diego, California), Dr. Jennifer Doudna (professor of biochemistry and molecular biology at UC Berkeley).

推荐阅读:

中文名 —— 《巨人的工具》

原名 —— TOOLS OF TITANS

—— 蒂莫西.费里斯 ( Tim Ferriss )著。

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